Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure
نویسندگان
چکیده
منابع مشابه
Loss of PPARγ expression by fibroblasts enhances dermal wound closure
BACKGROUND Peroxisome proliferator-activated receptor (PPAR)γ may be a key regulator of connective tissue deposition and remodeling in vivo. PPARγ expression is reduced in dermal fibroblasts isolated from fibrotic areas of scleroderma patients; PPARγ agonists suppress the persistent fibrotic phenotype of this cell type. Previously, we showed that loss of PPARγ expression in fibroblasts resulted...
متن کاملNanofiber-expanded human umbilical cord blood–derived CD34+ cell therapy accelerates cutaneous wound closure in NOD/SCID mice
Nanofiber-expanded human umbilical cord blood-derived CD34(+) cell therapy has been shown to have potential applications for peripheral and myocardial ischaemic diseases. However, the efficacies of expanded CD34(+) cell therapy for treating cutaneous wounds and its mechanisms of action have yet to be established. Using an excisional wound model in non-obese diabetic/severe combined immune defic...
متن کاملChitosan/nanosilver Nanofiber Composites with Enhanced Morphology and Microbiological Properties
In recent years natural polymers have been widely used in biomedical applications. Application of natural and biocompatible polymers in wound dressing, medical sutures and tissue engineering are extensively growing. Additional properties are provided when metal nanoparticles such as silver and gold are incorporated in to the fibers. However, nowadays nanofibers due to their inherent properties ...
متن کاملComparison of Primary Wound Closure with Vacuum Drainage and Delayed Closure in Perforated Appendicitis
Open wound managment after perforated appendicitis has been a common practice but recently, primary closure has been advocated to reduce costs and morbidity. For comparing delayed closures against primary closure with vacuum drainage, a randomized experimental study was designed. in Kerman. Sixty patients with perforated appendicitis divided randomly in two groups and evaluated on day of discha...
متن کاملA Novel Reticular Dermal Graft Leverages Architectural and Biological Properties to Support Wound Repair
BACKGROUND Acellular dermal matrices (ADMs) are frequently used in reconstructive surgery and as scaffolds to treat chronic wounds. The 3-dimensional architecture and extracellular matrix provide structural and signaling cues for repair and remodeling. However, most ADMs are not uniformly porous, which can lead to heterogeneous host engraftment. In this study, we hypothesized that a novel human...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-10735-x